How are you today? Well I’m feeling 150% better and this seems to have happened within the last 12-24 hours, since i went running and took my most recent dose of cabergoline. This is quite unusual and completely the opposite to what i have been experiencing these last 4-5 weeks.
My last post was only on Monday and i was feeling rotten but the change from then to last night and today is remarkable. It’s really odd but more of the same please! Yesterday I went out for an hour run and i can tell you it was a fight to get out! Usual lack of energy and motivation but i pushed myself to get out around Haigh Hall in Wigan with Joshlad towing up front
Slight deviation off subject here>>>>In the last week my old Wrestling Coach Roy Wood from Aspull Wrestling Club was at the Olympics with Olympian Maria Dunn from Guam whom he has been training for the last twelve months. Sadly she lost her first match and didn’t get a medal put all the same she is an Olympian! Anyway, Roy has some fabulous footage of himself as a young man wrestling at Riley’s Gym in Wigan under the legendary coach Billy Riley and whilst wrestling Billy says to Roy “Put some gusto into it.” I am only mentioning this as i now use this as my mental reinforcement to overcome my loss of motivation to exercise!
Getting back down to it, right now my head and sensations all feel completely normal and i don’t even feel tired at all. Later this morning I have an appointment at The Christie with the Professor and i am looking forward to sharing this update with him.
What gets me thinking is that after taking a dose of cabergoline, i generally feeling really odd and poorly but yesterday since taking the tablet at 3pm i feel quite fantastic! I went running then had the tablet with a sandwich when i got in and from there it’s been REALLY positive. I even made a nice meal for my girly and she commented that i had loads of energy. My girly by the way, Amy (as others too), has been FANTASTIC and i am very lucky to have her! It subtly reminds me what a fool i was back in the day but that’s behind me
So the question is why the sudden change in symptoms and why such positive impact of yesterdays dose of cabergoline? Did the running release endorphins and dopamine? I have been back exercising for a few weeks now and this hasn’t happened before?
As i read on a website for EXERCISE AND MOOD it is clear that there is a link!
As you know i have a prolactin secreting tumour and as i understand it and thanks to Wikipedia “Dopamine regulates prolactin secretion – Dopamine is the primary neuroendocrine inhibitor of the secretion of prolactin from the anterior pituitary gland. Dopamine produced by neurons in the arcuate nucleus of the hypothalamus is secreted into the hypothalamo-hypophysial blood vessels of the median eminence, which supply the pituitary gland. The lactotrope cells that produce prolactin, in the absence of dopamine, secrete prolactin continuously; dopamine inhibits this secretion. Thus, in the context of regulating prolactin secretion, dopamine is occasionally called prolactin-inhibiting factor (PIF), prolactin-inhibiting hormone (PIH), or prolactostatin.” Wowzers!
So it would appear that the pituitary function may be returning and prolactin levels may have reduced. On the subject of prolactin, i read an interesting forum thread the other day on Daily Strength about prolactin. Have a read as it explains the effect of prolactin on the male body! Perhaps the tumour has reduced in size and the pituitary gland is peeping out under the tumour. Fingers crossed that the pit gland has got back into working Anyway for today it’s all good and let’s see if it keeps up.
Thanks for reading.
Oh….as a footnote I have failed to mention the effects of Serotonin and Epinephrine which are the two other main neurochemicals in the brain that affect mood! Perhaps the Prof will enlighten me today.